Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/298127700?client_source=feed&format=rss
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Thursday, April 11, 2013
Wednesday, April 10, 2013
Suspect arrested in Texas stabbing rampage
A stabbing victim is loaded into a helicopter on the Lone Star College CyFair campus. (Reuters)
At least 14 people were wounded in an apparent mass stabbing at Lone Star College's CyFair campus in Cypress, Texas, on Tuesday morning.
The suspect, a white male armed with what one witness described as an X-Acto knife, was detained, police said. The suspect, believed to be 21, was enrolled at the school.
Harris County Sheriff Adrian Garcia said police received a 911 call at 11:12 a.m. local time reporting a white male "on the loose stabbing people."
The school was placed on lockdown.
"Seek shelter now," Lone Star College's Twitter feed warned Tuesday afternoon. "If away, stay away."
The incident occurred near and around the school's Health Science Center and remains an active crime scene, Garcia said.
"Buildings are still being searched," he added.
Four victims were transported by helicopter with serious injuries "consistent with laceration," a spokesman for the Harris County Sheriff's Office said. Two others were taken by ambulance to a local trauma center.
Two of those victims are in critical condition, he said. Four are in fair condition. Others victims were treated for minor injuries, and two refused treatment, Garcia said.
One witness told CNN that the stabber was hearing impaired.
An announcement was made over loudspeakers warning students to seek shelter. "This is an emergency," the announcement said, according to KHOU-TV. "Everybody stay inside of your rooms. Do not leave your rooms."
An alert issued on the school's website indicated that "another suspect may possibly be at large." But Garcia said surveillance video reviewed by police indicated there was one "and only one" suspect.
An Instagram user who said he helped apprehend the stabber posted a photo of a man face down on the ground with a backpack. He said the man had stabbed five people, including two girls in the cheek. "Everyone ran the other way ... ," he said. "Me and this kid got em." #copsaretooslow
Police would not confirm the exact weapon used, but said no firearms were found at the scene.
The campus was evacuated, Vice Chancellor Randy Key told reporters, and the college will remain closed for the remainder of the day.
In January, three people were wounded in a shooting at Lone Star College's North Harris campus near Houston. More than 90,000 students attend classes across the Lone Star College system's six campuses.
Source: http://news.yahoo.com/blogs/lookout/lone-star-stabbing-184840929.html
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Tuesday, April 9, 2013
Newly discovered blood protein solves 60-year-old riddle
Apr. 8, 2013 ? Researchers at Lund University in Sweden have discovered a new protein that controls the presence of the Vel blood group antigen on our red blood cells. The discovery makes it possible to use simple DNA testing to find blood donors for patients who lack the Vel antigen and need a blood transfusion.
Because there has not previously been any simple way to find these rare donors, there is a global shortage of Vel-negative blood. The largest known accumulation of this type of blood donor is found in the Swedish county of V?sterbotten, which exports Vel-negative blood all over the world.
The Vel blood group was first described in 1952, when American doctors discovered a patient who developed serious complications from blood transfusions from normal donors. The patient lacked a previously unknown blood group antigen, which was named Vel. It has long been known that around one in 1,000 people lack the Vel antigen, but the molecule that carries it has been a mystery.
Lund University researchers Jill Storry, Magnus J?ud, Bj?rn Nilsson and Martin L. Olsson and their colleagues have now discovered that the presence of the Vel antigen on our red blood cells is controlled by a previously unknown protein (SMIM1) that is not carried by those who lack the Vel antigen. The discovery has been published in the renowned journal Nature Genetics.
The findings have major clinical significance, according to Professor Martin L. Olsson, a consultant in transfusion medicine.
?Until now there has not been a simple way to find these blood donors and there is therefore a major shortage of Vel-negative blood. Now we can identify these donors with simple DNA tests. From having previously only had access to one such donor in our region, there are now three and further screening is being carried out?, says Professor Olsson.
Two research groups with completely different focuses have collaborated to solve the 60-year-old riddle, explains Reader Bj?rn Nilsson, who has led the work together with Reader Jill Storry and Professor Olsson.
?Many researchers have tried to find the Vel molecule. We realised that it might be possible to find it using advanced DNA analysis techniques. Our idea proved to be correct and we found that the Vel blood group is inactivated in exactly the same way for all Vel-negative individuals?, says Bj?rn Nilsson.
Another interesting aspect is that the new protein is unlike any previously known protein and appears to be present on the red blood cells of other species as well.
?Interestingly, the new protein, SMIM1, is reminiscent of other molecules used by malaria parasites to infect humans. It is therefore possible that SMIM1 could be a long-sought malaria receptor on the red blood cells?, says Jill Storry.
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The above story is reprinted from materials provided by Lund University.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Jill R Storry, Magnus J?ud, Mikael Kronborg Christophersen, Britt Thuresson, Bo ?kerstr?m, Birgitta Nilsson Sojka, Bj?rn Nilsson, Martin L Olsson. Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype. Nature Genetics, 2013; DOI: 10.1038/ng.2600
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/JadEVxGEcR0/130408122806.htm
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Engineered T cells kill tumors but spare normal tissue in an animal model
Monday, April 8, 2013
The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer. Identifying which antigens a patient's tumor cells express is the cornerstone of designing cancer therapy for that individual. But some of these tumor antigens are also expressed on normal cells, inching personalized therapy back to the original problem.
T cells made to express a protein called CAR, for chimeric antigen receptor, are engineered by grafting a portion of a tumor-specific antibody onto an immune cell, allowing them to recognize antigens on the cell surface. Early first-generation CARs had one signaling domain for T-cell activation. Second-generation CARs are more commonly used and have two signaling domains within the immune cell, one for T-cell activation and another for T- cell costimulation to boost the T cell's function.
Importantly, CARs allow patients' T cells to recognize tumor antigens and kill certain tumor cells. A large number of tumor-specific, cancer-fighting CAR T cells can be generated in a specialized lab using patients' own T cells, which are then infused back into them for therapy. Despite promising clinical results, it is now recognized that some CAR-based therapies may involve toxicity against normal tissues that express low amounts of the targeted tumor-associated antigen.
To address this issue, Daniel J. Powell Jr., PhD, research assistant professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, and director of the Cellular Therapy Tissue Facility, developed an innovative dual CAR approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.
Powell likens this dual CAR approach to having two different gas pedals, one for starting the immune system and a second for revving it up. Dual CAR T cells are more selective for tumor cells since their full activity requires interaction with both antigens, which are only co-expressed on tumor cells, not normal tissue.
Dual CAR T cells showed weak cytokine production against target cells expressing only one tumor-associated antigen in lab assays, similar to first-generation CAR T cells bearing the CD3 activation domain only, but demonstrated enhanced cytokine production upon encountering natural or engineered tumor cells expressing both antigens, equivalent to second-generation CAR T cells with dual, but unseparated signaling.
In a mouse model of human ovarian cancer, T cells with the dual-signaling CARs persisted at high numbers in the blood, accumulated in tumors, and showed potent anti-cancer activity against human tumors. Dual CAR T cells were equivalent to second-generation CAR T cells in activity against tumors bearing two antigens. However, the dual-signaling CAR T cells did not react vigorously with normal tissue expressing one antigen while second- generation CAR T cells did.
"This new dual-specificity CAR approach can enhance the therapeutic efficacy of CAR T cells against cancer while minimizing reactivity against normal tissues," says Powell.
Their findings have been published in the inaugural issue of Cancer Immunology Research, the newest journal from the American Association for Cancer Research.
###
University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/
Thanks to University of Pennsylvania School of Medicine for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Monday, April 8, 2013
China reports 2 more cases of new bird flu virus
BEIJING (AP) ? Shanghai has reported two more cases of human infection of a new strain of bird flu, raising the number of cases in eastern China to 20. The death toll among those who contracted the virus remains at six.
Health officials believe people are contracting the H7N9 virus through direct contact with infected fowl and say there's no evidence the virus is spreading easily between people.
China's official Xinhua News Agency reported the two new Shanghai cases Sunday, citing local authorities.
Shanghai has been ordered by the agriculture ministry to halt its live poultry trade and slaughter all fowl in markets where the virus has been found.
The capital cities of the neighboring provinces of Zhejiang and Jiangsu also have suspended sales of live poultry. Both provinces have reported H7N9 cases.
Source: http://news.yahoo.com/china-reports-2-more-cases-bird-flu-virus-123620810.html
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Sudan officers get jail terms for alleged coup attempt
KHARTOUM (Reuters) - A Sudanese court sentenced nine army officers to prison terms of up to five years on Sunday for their role in an alleged coup attempt against President Omar Hassan al-Bashir, a lawyer said.
In November, Sudan arrested its former spy chief Salah Gosh and other senior military and security officials after foiling what the government says was a coup plot.
In the first verdict since the arrests, a military court in the capital Khartoum handed down jail terms of between two and five years to nine army officers, said Hisham al-Ja'ali, a lawyer for the defendants.
"They were also dismissed from the armed forces," he told Reuters, adding that another officer had been acquitted of all charges due to a lack of evidence and set free.
Among the convicted is Wad Ibrahim, a senior officer and prominent Islamist in the army, who got a five-year jail term. The trial of Gosh and the accused security officers has yet to start, the lawyer said.
There was no immediate comment from the government, which has refused to provide details of the coup attempt or the investigation.
Bashir has ruled Sudan for 23 years, weathering multiple armed rebellions, years of U.S. trade sanctions, an arrest warrant from the International Criminal Court and the loss of most of the country's oil with South Sudan's 2011 secession.
The alleged coup attempt amplified a debate about Bashir's future and about who might one day replace him.
High food prices in Sudan caused by the loss of the oil - and with it the source of foreign currency used to import wheat and other staples - has stoked some protests against Bashir since the South seceded in July 2011.
Some Islamists inside the army and the ruling National Congress Party have also complained that Bashir and other senior leaders have abandoned the Muslim values of the 1989 coup and concentrated decision-making in the hands of a few people.
But Sudan has avoided the sort of mass unrest and political turmoil that unseated rulers in neighboring Egypt and Libya.
(Reporting by Khalid Abdelaziz; Writing by Ulf Laessing in Cairo; Editing by Stephen Powell)
Source: http://news.yahoo.com/sudan-officers-jail-terms-alleged-coup-attempt-164918101.html
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Sunday, April 7, 2013
Get more tax mileage from your car ? Business Management Daily ...
Q. A recent article ("Put business car deductions in gear") about using a vehicle for business said a taxpayer will likely do better deducting actual expenses. But isn?t this misleading? J.A.M., E.A., Clarksville, Tenn.
A. Not for a short answer. Of course, the exact outcome for any given situation will vary, depending on the circumstances, including the business miles traveled and the amount of expenses.
However, in a year when 50% or 100% bonus depreciation is available, the actual expense method will often generate a much larger deduction than the standard rate (56.5 cents per mile in 2013; 55.5 for 2012), taking all the applicable expenses into account.
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